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when your stomach starts hurting like shit and everyone and everything pisses you off and you have to RUN to the toilet before you shit on yourself
Ouu my stomach hurts , leave me tf alone , i think i have the runs .
The Runs by bubbeguppy July 2, 2019
Shelby: oh shit I’ve got the runs again 🏃🏼 ♀️
Eleanor: Olby you always need the runs you got some runny poop 💩
The Runs by HiyaO07 October 31, 2019

The Runs of Anarchy 

A sudden and uncontrollable bowel movement so violent that chaos and anarchy are unleashed down both legs of ones corduroys.
Sorry about the smell folks, ive got The Runs of Anarchy. I had a broccoli omelette for lunch. And had seconds.
The Runs of Anarchy by Broxibear72 February 22, 2023

I wish you the runs 

To cordially wishith upon the runs/diarrhea to someone/something
Someone cuts you off while driving on the road: "I wish you the runs"
I wish you the runs by J-Bye January 17, 2009

to have the runs 

to have the runs
To have the runs. When food is not properly cooked or if one drinks water unfit for human consumption, one invariably has diarrhea. "The person has the runs". He has to run very quickly to the nearest toilet so as not to release his bowels in his pants.

Buns to the runs. 

Phrase. When one has runs coming out of their buns.
"Got the buns to the runs my man...buns to the runs."