A mixture of poop and puke. It can emit from either the throat or the anus and is equally surprising either way. Projectile pupeing has been observed in highly intoxicated individuals.
by Bob "the dream" Oregano March 28, 2005

that poop you take that also makes you sick and shivery. you're on the toilet crapping when you suddenly feel nauseous. pupe is a mix of the words poop and puke.
by aislinntheace April 8, 2009

the natural bowel movement caused from an all-you-can-eat mexican buffet, when gallons of acid come screaming out your anus causing it to burn your anal hairs, while releasing the rest through your mouth
Smokin hot bloody pupe came rushing out of me after going down on my girlfriend and getting a mouthful of herpes
by wizard_of_xtc May 5, 2005
