Taken literally, it is a combination of four (4) diseases,
(Gonorrhea, Herpes, Syphilis, and AIDS) and is used to describe a person, usually a girl who is known to be very slut-like and/or disease ridden.
I chose not to have sexual with the stripper because I realized that, although hot, she had gonoherpisyphilaids.
A generic term used to describe a person that is very suspect of having an STD but the exact one is not known. It incorporates all the major ones: gonorrhea, herpes, syphilis, and aids.