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23 Skidoo 

The drip, crotch-nasties, the gift that keeps on giving...

Yes, an STD. (generally chlamidiya, gonnorhea, something that can be treated with penicillin or Cipro).

This phrase was used a lot in the circles I hung out with in the late 80's/early 90's.
Keith: "I was gonna do her, but I sniffed her coochie and realized I'd get the 23 skidoo from her."
Thomas: "Dude, that sux you didn't get any, but it beats going to the doctor."

OR

Keith: "Yeah, I did her a week ago, and I had to go to the doctor today to get rid of the 23 skidoo she gave me. Fuckin' whore!"
Thomas: "Shit, that sux man. I won't tell anyone." "HEY, MIKE! KEITH GOT THE 23 SKIDOO FROM DONNA!!!"
23 Skidoo by Corporal Grumpy July 29, 2006
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covid 23 skidoo

the most dangerous type of covid...the one that will put you under.
yeah Jim was a real card..he had he died from covid 23 skidoo engraved on his headstone.
covid 23 skidoo by pussy bee November 8, 2020
Related Words
During the 1920's in the United States the social group that came to be known as "flappers" often used this phrase as a means of telling someone to "get lost," or to "scoot."
Flapper Guy: "Hey doll your dreamboat just sailed in..."
Flapper Girl: "23 Skadoo you soda jerk!"
23 Skadoo by THEREALJULIA April 16, 2006

23 skiddoo 

to leave quickly, especially before a situation deteriorates (archaic, origin unknown, popularized during 1920s)
He felt it was the best moment to 23 skiddoo.

23 Skiddoo 

The act of taking a shit. Often associated with with a meal that tends to quickly induce a bowel movement such as fast food.
We just got Taco Bell. I'm gonna have to 23 skiddoo any minute.

Q : "The bathroom smells awful, what did you do in there?"

A : "23 Skiddo!"
23 Skiddoo by Thedteamhr January 29, 2010
a term used by kitty foreman on that 70's show. pretty much the best expersion ever.
sam "i didn't have to go to that hellhole called work today!!"
hannah "well 23 skadoo"
23 skadoo by miss darling August 2, 2007

23 skiddoo 

A wind (especially a tornado alley in a city) that blows girls' skirts up. Also, get going, move along, leave, scram, beat it.
You were supposed to have left an hour ago! Get movin' already! 23 skiddoo!
23 skiddoo by Jay Young January 15, 2004