What happens when you combine a crackhead and a tweaker, they are the most dangerous humans to ever walk on the earth. They are very unpredictable, have Usain bolt speed, and generally act feral. they are most likely addicted to atleast 4 different drugs. They have viciously long nails and lemon yellow teeth. They can sniff out drugs from miles away, if you have ANY sort of substances they want, you better give it to them or you will get mauled.
1. "Ayo what's that crackhead tweaker doing over there? Oh, he's scavenging for a grain of cocaine."
2. "You better give that crackhead tweaker you pills or he finna maul you"
2. "You better give that crackhead tweaker you pills or he finna maul you"
by STL446 May 20, 2023

When a person who is addicted to drugs picks their face to the point of looking like they have a severe case of chicken pox.
Britney Spears’s husband showed up at her wedding with tweaker pox and got tackled and arrested for trespassing…
by Tbone diddley June 11, 2022

People who are jacked up on coffee. Often have bad breath & can be easily spotted because they almost always carry a thermos everywhere they go. They drive too fast, talk too fast & are some of the most annoying people on the planet.
I thought that bitch had undiagnosed ADD, but when I smelled her breath I realized she was a coffee tweaker.
by evablogger August 23, 2016

An uncontrollable spastic muscle twitch or other unnatural jerk that is a tell tell sign of long-term meth use or signs of getting ahold of some bad shit.
MK- " man, I know he's getting high "
HB - " who?"
MK - " my brother"
HB - " are you serious? How do you know"
MK - " see how the corner of his mouth is all weird and twitching, kinda like a fucked up Elvis lip? That's his tweaker feature"
HB - " no shit? Man that's weird AF"
HB - " who?"
MK - " my brother"
HB - " are you serious? How do you know"
MK - " see how the corner of his mouth is all weird and twitching, kinda like a fucked up Elvis lip? That's his tweaker feature"
HB - " no shit? Man that's weird AF"
by 'Denver's Finest' October 13, 2022

After you have done a little too much methamphetamine and think people are in your yard, so you continuously look out the blinds until they are bent back on some parts
by lucyinthesky91 September 19, 2018

by #Xyzbca October 10, 2021

The type of tweaker that goes behind you and mixes up all your organization, robs you, and/or lurks in the shadows and does the unknown worst kind of ugliness and meaness.
Those underground tweakers took our lawn furniture to Tom's and brought his lawn mower over to our pool for a swim last night.
by Rhodhisian May 29, 2017
