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I'm coming, Elizabeth! 

The most well-known catchphrase on SANFORD & SON. Whenever Fred Sanford heard something particularly distressing, he always staggered around clutching his chest and shouted to his deceased wife, "This is the big one! I'm comin' Elizabeth!" This particularly applies to whenever you hear some really awful, distressing news, bad enough to make you think you were having a heart attack.
YOUR BOSS: I'm afraid I have some bad news: you won't be getting your bonus, I need you to work overtime next week, and your car's just been impounded.
YOU: Oh, my God! This is the big one! I'm coming, Elizabeth!
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I don't give a shits 

An ailment that causes one to not care about the consequences of their actions or give up on their goals.
"Hey man, you're getting fat again. What happened to your diet?"
"The I don't give a shits came early this year."
Related Words
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I mean, what? 

I'm gonna kill that asshole. I mean, what?
I mean, what? by baileyx January 13, 2009

I Like You, Dude 

Something very gay to say to a total stranger
"I know you said you weren't here to make friends, but i like you, dude."

I reject your reality and substitute my own. 

A quote from the low-budget sci-fi/fantasy film The Dungeonmaster, popularized by Adam Savage of Mythbusters, this quote basically means "you may be technically right, but you're not changing my mind." This can come off as stubborn, but it really doesn't matter, since you don't care about the technical "facts".
Person 1: Ugh this character's design is so terrible and pointless.
Person 2: Well actually, did you know that it's design comes from goes on to prove person 1 wrong
Person 1: I reject your reality and substitute my own.
Person 2: -sigh- Okay then, moving on...

i'll give you that 

it means I admit that, I admit it.
You have a nice body, i'll give you that, but what about your face? IT'S UGLY!!!!
i'll give you that by TaylorFTW September 2, 2012