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The American definition:

1.) An excitable, hyper, or jittery person.

2.) To act in a wild manner.

As defined by white disabled activists from the UK on twitter:

1.) An ableist slur short for "spastic" or "spasticity"; which directly refers to Spastic Diplegia, and anyone (preferably those with power and followers) who uses the term in any context outside of medical science must apologize and be ashamed for having used it.
United States: This kid I'm babysitting is such a spaz. He gets one piece of candy in him and he's bouncing off the walls.

United Kingdom: Even though we call "fags" cigarettes in the UK (and no one has cancelled all of Britain yet), when Beyonce and Lizzo used the word "spaz" in a jovial context, we fought on social media to bring worldwide attention to the NEGATIVE connotation.

Also UK: "Spaz" has historically been a part of African American English Vernacular, but any disabled people of color from the US disagreeing with us will be a.) ignored in the conversation on Twitter, or B.) be accused of "reverse racism".
Spaz by UnknownCryptid January 18, 2023
Related Words
A word used to describe someone that is hyper. It is usually directed at someone who is attention deficit or sped.
"sit down spaz"

-The Benchwarmers
Spaz by Bezznzz April 12, 2023
Spaz‚ short for Franchi SPAS-12 is a combat shotgun designed and manufactured by the Italian firearms company Franchi from 1979 to 2000. It is known for its distinctive appearance and dual-mode operation, allowing the user to switch between semi-automatic and pump-action firing modes. This feature made it versatile for both military/law enforcement use and situations where less-lethal ammunition (like rubber bullets) might be used, which typically don't cycle semi-automatic actions reliably.
Bro did you really pull out a Spaz in the news?
Spaz by shaodwoz June 21, 2025

spaz car 

A three wheeled vehicle distributed to the handicapped by the British Government in the 1970s (some kind of conspiracy to eradicate them perhaps). They all came in the same ugly light-blue colour.
"Urgh...look at John's cardigan, it's spaz-car blue!"
spaz car by Twizla January 26, 2005

spaz-wazz 

When someone goes crazy over correcting a paper or something of the like.
I spaz-wazzed all over that paper that my friend handed me.
spaz-wazz by CaveStoryManic June 15, 2015

spaz drag 

When your hand suddenly spaz's out and you move a folder on your network somewhere and you have no idea what folder it was or where it has gone
I just spaz dragged a folder and I have no idea what's happend to it!
spaz drag by JW101 May 10, 2016