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A game being devopled by Maxis(Simcity, Sims) and produced by EA. You start as a simple single-cell organism and evolve into a space-fairing civilization. There are 6 stages to the game.

1.Cell stage
2.Creature stage
3.Tribal stage
4.City stage
5.Civilization stage
6.Space stage

The game is to be released fall 2006, and is expected to be very good.
Wow, Spore looks like it will be very cool.
Spore by derekwashere April 19, 2006
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an awesome game that has already been released. not as good as it first looked, but it's still a great game
spore by antonio pasqualonea January 20, 2009
Stupid People On Rental Equipment. Generally refers to inexperienced people on ski slopes who are likely to injure themselves and/or others; being inexperienced, they typically do not own their own ski's and must use rental equipment.
Woah, looks like BrYan just wrenched his ankle on those rental skis. He really is an example of a spore.
Spore by Derek Exler August 2, 2008
A widely played game that lets an 8 year-old boy watch their older siblings or relatives make monsters with penises that are at least 10 feet long and then turned into giant monsters that jump and give you a massive tea-bag.

Trust me - I would know.
8yearold: Dude! The only thing I can see is that one's giant penis and I can't see anything!
Person: MORE! MORE! MORE! I love Spore!
Spore by THESMARTANDDUMB December 31, 2008
A game by the famous Will Write. As I write this it's release date is a year or so away, but it will be sure to rock the gaming world.

For the PC.
OMG Spore is sposed to come out in Fall 2006 you say!?
Spore by Flash Fan August 29, 2005
Greatest game not released yet. Developed by Maxis and already is in the final stretch of production. 6 modes of play too.
spore by Qualanx May 21, 2006
This word stands for >> stupid people on rental equipment. It was made after many many stupid manouvers.
Look at that stupid spore heading towards the open water on his snowmobile.

There are seven of the spores on one machine.
Spore by Permafrost November 4, 2004