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sissiphant 

A very prissy stuck up girl.
A girl who considers herself to be on top socially.
A derogatory name for a uptight or squeamish preppy girl.
Most girl's in highschool aspire to be total sissiphants.
Cindy's chronic fear of spider's made her considered to be a sissiphant amoungst her peers.
sissiphant by Jan Smith February 4, 2008
Informal nickname for a really fun, cool, authentic, funny, and laid back sister and/or closest friend.
Dude, me and my closest sissel were totally talking about that the other day!

sisseton 

A small desolate hicktown in northeastern SD. Full or hillbillies who love Chinese buffets, drinking at sad lonely bars and infesting the world with more hillbillies,

Used to describe a sad no light at end of tunnel ever state of mind.
My car is totaled, and she has a new man, I'm broke now. My dog is living in peever flats shacked up. Now I know what it's like to live in sisseton
sisseton by Red hand February 19, 2020
A combination of sis and homie

A word to call ur sis and homies

hI sIstErs
(word credit to my sismie: joods)
SarA wAS waLkiNG tO scHool aND mEt ClArA anD ?????

????? & Clara: Hi sismie!

Sara: Hey sismies,,
Sismie by georgeynoot August 25, 2020

Sissione 

Is a girl who can't keep secrets. She is such a huge pick mee. She is a hoe and date's boys for attention.She may/may not shower
Sissione is such a pick mee ugh.
Being robbed of a cup in beer pong due to rimming out.
Kiss those damn cups, its like Sissler's revenge up in this bitch!

I feel like Shaq trying to make a free throw, is Sissler in this room?

(After rimming out) SIIIIISSSSLLLLLEEERRRRRR!!!!
Sissler by Po Pong Master November 14, 2011