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defriend 

(v) To remove someone from your livejournal friends list.
"I defriend people who post quiz results. Get a life!"
defriend by Coell May 14, 2005

Defriend 

The act of deleting someone on an online socializing site like Facebook or Myspace.

This usually happens when someone you don't know requests to be your friend so you accept them to see their profile. Once you realize that you don't know them or that they are a complete creeper, you attempt to 'defriend' them. This usually proves to be a nuisance and a pain to figure out how to do.
Person 1: I'm going on this trip to France and a guy from another school friended me, I messaged him 'cause I wasn't sure who he was, and he gave me a total creeper response.

Person 2: Man, defriend that fool.
Defriend by B-RizzleforShizzle March 4, 2009

Defriendization 

A large-scale deletion of friends from a social networking site. Similar to deforestation, it can have drastic effects on the remaining landscape of your friends list. The people you unfriend may then Facebook chat rape or Facebook stalk your mutual friends, asking why you've cleared an entire forest of people.
"I had to do some serious defriendization on FB after I dumped my stupid ho. No big deal, I hate her skanky, retarded friends anyway. Sorry if they come after you asking what happened, just tell them to get stuffed."
Defriendization by Rubenonfire February 6, 2010

defrienestrate 

To break off online relationships by throwing your computer out a window.
John was so tired of Sarah's frequent inane status updates that he defrienestrated her and lost his new MacBook.
defrienestrate by Brebro November 6, 2009

Defriendsive

V. The Act of Defending a person simply because of a friendship, often when the friend in question has done something wrong.
Girl: "Look that girl is a little crazy sometimes, but hey everybody is!"
Guy: "You're just being defriendsive."

Man 1: "Did Aaron steal my muffin?"
Man 2: "No dude! YOU LEFT IT IN THE RESTAURANT. SERIOUSLY, WHY WOULD YOU ACCUSE HIM OF SUCH A TREACHEROUS DEED."
Man 1: "Why are you getting so defriendsive all of the sudden..is something going on?"

Defriend 

To remove a friend from your Facebook or Myspace because you misfriended them (accidentally "friended" them or added them as a friend).
I had to defriend this dude I thought I knew from my high school days, but it turned out I didn't. He was sending me all sorts of events spam!
Defriend by Sartorialist February 25, 2009