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When you take too many drugs and something so awesome, say a live concert, causes the back of your head to explode.
I totally JFK'd when I saw Tool at Bonnaroo.
JFK by Robby Hart July 19, 2009
Aside from the president, this name is commonly know amongst dance punk/electro lovers. All because of Jesse Frederick Keeler, former bassplayer of Death from Above 1979 and currently one of the two DJ's in the DJduo MSTRKRFT.
1#: "Dude, this rocks, what is it?"
2#: "Death from Above 1979..."
1#: "Definitely want to see them perform live"
2#: "Too bad they broke up long ago"
1#: "Why!"
2#: "The bassplayer, JFK, seemed to have serieus arguements with drummer Seb..."
1#: "Too bad..."
JFK by GraingerIV February 18, 2009
A Starbucks Coffee with 3 shots. One shot is a Red Eye; 2 shots is a Black Eye; 3 shots is a JFK because its the 3rd shot that will kill you!
I was so jacked on caffeine after that JFK, i thought my head was going to explode!
JFK by jdohmc December 9, 2009
You hear that Rick's wife gave him back the house?
No!
JFK!
JFK by Curt Custer October 28, 2003
A JFK is getting your head "blown" while driving in a car.

Analogy: Roadhead
Yo Rich, I couldn't answer the phone because Latoya was givin' me some JFK!

Possible cellphone greeting: Sorry I can't answer the phone right now, I am busy getting a JFK. Please leave a message after the load.
JFK by BBT0101 April 2, 2008
When a married Hindu lady is blowing your trumpet and you take a step back just as you're about to bless her with you magic sauce. As you step back you aim right at her Bindi as if you're a sniper assassinating her with a headshot.
Friend 1: I heard Jack's Hindu girlfriend broke up with him.
Friend 2: Yeah, it's because he almost blinded her by failing to execute a proper JFK.
Friend 1: Pfft, rookie.
JFK by RhinoIV November 3, 2019