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Up in this bitch 

The Swahili term used on the Orange River, the border of South Africa and other neighboring countries, referring to intense shit going down.

Alternative phrases include "up in this world" and "YO MAN" however they all hold the same meaning, up in this bitch!
"Damn nigger! That shit be crazy up in this bitch"

This can refer to any circumstance when you are overly excited for a reason, or just tripping balls. Traditional geographical locations for use of this term are majorly used while rowing down the Orange River.
Up in this bitch by Rifle/Rafe October 14, 2011

Up In This Piece 

Means the same thing as,wh ats going on
whats up in this piece?
Up In This Piece by Falze October 9, 2006

It stank up in this bitch. 

There is a very bad smell in the building/structure you're currently in.
Jessica: What is that smell?
Jordan: Yeah! It stank up in this bitch.

clean up in this hoe 

This clearly means to spray windex into your hoe after anal sex. Gotta keep those hoes streak free!
After anal sex, I clean up in this hoe. Now I need more windex.
clean up in this hoe by Amerin November 14, 2007

get up in this 

A typical invitation issued by PC gamers, typically at a LAN or gaming center, encouraging someone to get on a PC and join the game. It is typically accompanied with a standard issue insult, such that said gamer will now be obligated to play in order to prove his/her worth as a gamer.
"I see we got some DoD goin on"

"Fuck yeah, get up in this, bitch!"
get up in this by bowling March 13, 2008

Go all Wolfman up in This 

To throw away one's razor. To swear off shaving any part of the body.
Bruce decided to go all wolfman up in this, and now has a big bushy beard