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A formerly good looking person who recently has gotten a mullet.
Also, a social outcast.
Person 1: Have you seen Billy Carrabino's haircut?
Person 2: Yeah, he's turned into a leper cause of that mullet he got.
leper by CTdoglovrr February 8, 2012
1.For the use of lesser words; the slang use for a "crankhead"

2. One who tries too hard in life to be cool, knowingly knowing that they aren't but somehow pretend they are.
Man that dude with the shades on in the club is a leper.
Leper by Breezy F. Baby September 2, 2007
Shane "skinbad" Comofort,
irish form of a leper
Guy 1: that guy's arm just fell off!!!
Guy 2: maybe its shane comfort?
Guy 1: oh yeah, never mind
leper by Anonymous September 25, 2003

leper colony 

The designated smoker's areas outside of office buildings or in airports.
I hate walking by the leper colony in the morning...it stinks!
leper colony by Zenanarchy June 17, 2018

Leper Lepellier 

Boy from John Knowles's A Separate Peace. A recluse and continually scorned by the other boys at Devon for avoiding the war (World War II) Leper is like the punching bag and sad sack. Eventually, he succumbs to insanity after having to endure the harshness of training for war, never actually making it out to battle.
Brinker Hadley was one of Leper Lepellier's main antagonists, rejecting him because he feels he is too much of a "naturalist."

Leper Colony 

That group of kids everybody knew in high school that individually were often the targets of derision and/or physical violence, but who through some geek radar found one another to form an alliance, thereby lessening the probability that any one member is a victim.

The reference to the middle-age practice of isolating individuals with Hansen's Disease (Leprosy) and not allowing them to come into contact with any "normal" people is apropos because if a "normal" (read non-geekified) child were to associate with the leper colony, s/he is immediately labeled as suspect, and in extreme cases will be isolated him/her self, thus becoming a member of the colony.
Mark's sister: "Mark has been indoctrinated into the Leper Colony and is at the park LARPing."

Mark's mom: "NO GOD, NOOOOOOOO!"
Leper Colony by cowboythecat October 28, 2010