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Sexual Frustration Syndrome (SFS) 

A scientific-sounding phrase that can be used to suggest a treatment - sex - by a potential sexual partner (usually a guy - duh).
I am doing an experiment on cures for Sexual Frustration Syndrome (SFS) - would you like to join my study?
sfs - seriously funny shit.

Mostly used when telling someone else of something funny that you have seen or heard of.
Person A: I just watched anchorman, that is some sfs.
sfs by non_stop.dance_party June 28, 2010
So Fucking Stupid. Used to describe a person that is so fucking stupid or yourself for acting or being so fucking stupid at that moment.
Example 1: WOW! That girl just said something about me when i was TWO FEET AWAY!! ...sfs

Example 2: I just ran into a door.... sfs
sfs by Sweet HoneyBee 5381 September 6, 2011
The shine on that Dusty marble is SFS!
SFS by masterglenn October 14, 2011
Acronym for Standard Fantasy Setting. You got your elves, dwarves, goblins, swords, and magic. If you can't talk about it without referencing the Lord of the Rings or Dungeons & Dragons, it's probably in the SFS.
"I'm making a game about dwarves, but it's not in the SFS cause they're like actual dwarves who work as tax accountants."
SFS by TeenageAngst July 28, 2013
Shit-faced shitting. When you get so drunk and wasted, such as during a ring dunk ceremony for a certain, infamous, university, that you start blindly shitting like a goose everywhere without due regard.
Bob: "Hey, is Joe in the bathroom still?"
Jill: : "Yeah, but don't go in after him. SFS everywhere."
Bob: "Cool, thanks".
SFS by Rearmount September 24, 2014