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1. A way to shorten the phrase whats up. When your saying hello to a lass, its easy to say whayup rather than whats up.

2. A verb to express either jizzing, shitting, or anything that involves domination.
1. Bobby: Oh hey Jennifer, whayup!

Jennifer: Not alot Bobby, how are you.

2.

Guy 1: Bro I just whayuped all over Stephanie's face after she gave me head.

Guy 2: Dude, that's whayup.
Whayup by yanni33 January 29, 2010
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Whatupdoe 

a word used in Detroit and surrounding areas.it's a greeting that Detroiters use to say what's happening.
Whutupdoe nigga? Nothin much what up wit you?
Whatupdoe by Imperial313 October 26, 2004
Related Words

WHADUP DAWG 

A way of saying hi to your friend
WHADUP DAWG by Mark April 14, 2003

whatup wednesday 

an intimate gathering of friends and strangers that takes place on a wednesday night and generally involves a fair amount of alcohol in a small dorm room. originally created by 4 south-campus ucla students who needed an alternative to the normal thursday outing.

whatup wednesdays have been evolving, including a theme song, an official shirt that is worn on wednesdays, a constitution, and more. the goal of WW is to be recognized as another day to celebrate during the rough and tough of college life.
Guy 1: Dude did you hear about whats going on today?
Guy 2: Isn't it only wednesday?
Guy 1: No its WHATUP WEDNESDAY!
Short for "what is up" / "what's up"
"Hey Man whadup" / "Whadup dude"
whadup by R172 March 2, 2008

That's Whasup 

To describe something cool, nice.
Man 1: Tonight we are going to the movies.
Man 2: All right, that's whasup!
That's Whasup by renanfj November 14, 2007

whatupskee 

Created by rapper JJ Demon. It's the crunk way to say what up bitches? Or how's it going. It is slang too. Or sup? Anything that is asking some one whats going on. Whatupskee?
Yiz-zoh! Whatupskee bizznitchez? Whats crackin hoes?
whatupskee by LaceSixxTheDemon June 27, 2011