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a variation of "first" posted to an online comment section to indicate that you were the first to post. the "i" and "r" often are intentionally transposed to convey the typist's haste.
toolbox full of feminine hygiene products: "I was first to comment on this article about oleophobic cell phone screens, yessss! I typed "frist" instead of "first" because I was in a big hurry, get it??"

God, all of humanity, and Bill Frist: "STFU"
frist by moggison September 25, 2010
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v. To constantly change one's views on 'hot-button' political issues in order to satisfy the voter contingent. The purpose of this is generally to gain favor for a bid in an important election.

etym. Named after Sen. Bill Frist, who changed his opinion on stem-cell research in order to align more with that of the public's.
A lot of people would retrospectively accuse John Kerry of fristing during the 2004 election campaign.
frist by RehabbedMacAddict June 17, 2006
Related Words
Fat wrist. When there is no narrowing between the forearm and hand, you have a frist.
I broke my wrist and had surgery! It is so swollen, my friend and I decided I have a frist!
frist by Tiffany W February 27, 2008
Similar to a 'cankle'. The Frist resides on the arm where the wrist should be. Forearm to hand with no transition.
Jen is so fat, she has fupa, cankles, and frists.
frist by Ken Mallo December 31, 2005
v. fristed, frist·ing, frists
v. tr.
1. To assert ones opinions as fact, based on extremely limited information, esp. in contradiction of others who have first-hand understanding of the facts.

2. To do the above in some official capacity, i.e. testimony in a judicial proceeding or legislative debate.

n.
1. One who has a propensity to do the above, or does so on a hired basis.
"That patient had numerous doctors examine her who all concluded she is brain dead. Don't try to frist me!"

"'Don't worry,' the attorney told the fake accident victim, 'I have a lot of frists I can coun't on to claim you are badly injured.'"
frist by Eva Doer July 11, 2005
A mystery word that can mean anything when used in the right context.
Guy 1: WATCH IT BUDDY, OR IMA SHOVE MY FRIST UP YOUR ASS!
Guy 2: Um....okee then. What exactly is a frist?

Guy 1: YOU WANNA FIND OUT BITCH?!?
Guy 2: No, not really...sounds kinda gay...
Frist by HannibalLickedHer December 10, 2009
v. To give an opinion that one is not fully qualified to give.
Yeah, my bank lawyer suggested that I try and sue the hospital for malpractice when I got an infection after my surgery. I don't know if I'm going to believe her, since it seemed like she was totally fristing.
frist by RehabbedMacAddict June 17, 2006