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McGuffin 

A phrase used in detective stories to describe the one vital clue that causes the whole plot to fall in to place.
Eg.

"I couldn't figure it out...until I saw the tube of toothpaste."
McGuffin by The Truth October 20, 2003

McGuffin 

A burger from Amazing World of Gumball that means Stupid Mushroom

I made this to tell my brother I was right
I present to you, the McGuffin
McGuffin by Pudding.qq_ November 27, 2021

Mcguffin 

When a female wears a pair of colored leggings and their crotch sweats and the wet spot seeps through the leggings and is visible to everyone
My crotch was feeling sweaty and pilates and I looked down and I had a Mcguffin in my light blue leggings
Mcguffin by Dirtydentist September 21, 2022

mcguffin 

A word discovered in the 17th century by viking hoarders. The literal translation refers to a tangible something that is the same or shares similar qualities with another.
mcguffin, homes.
mcguffin by zoobinthe3rd May 12, 2011

Mcguffin 

A mcguffin is an extremely obese, gravy guzzling racist bastard.
That fat fuck mcguffin fired another black person today. Big surprise. He had to stop to take deep breaths in between each word. He almost passed out from high blood sugar.
Mcguffin by Dienaziscum August 13, 2020

Mcguffin 

An ingrown asshole hair (daverna), that has been popped.

See also daverna
Wow that mcguffin is still secreting puss
Mcguffin by Isaiah Dyddertwyce September 5, 2025