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This is a district under the government of a prefect (or prefecture) in Greece. It's made up of a number of islands in the Aegean Sea.

According to Greek mythology, the god of the islands was called 'Lesbos.'

An ancient poet called Sappho wrote about love between women about 2700 years ago and that's where we get the term 'lesbian' from.

Apparently, Sappho's poetry was pretty hot stuff and the Christians didn't like it. Little of it remains today thanks to a policy of it being destroyed by those against it.
Greek 1: "Behold! Across the Aegean sail the lovers Clitus Enormos and Vulva Maximus from the islands of Lesbos!"
Greek 2: "I'm hard as a temple pillar already!"
Lesbos by Wizards Sleeve July 15, 2008
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a Greek island located in the northeastern Aegean Sea. People from lesbos are called lesbians.

"The word lesbian is derived from the poems of Sappho, born in Lesbos, which contain powerful emotional content directed toward other females and have frequently been interpreted as expressing homosexual love."
That gurl lives in lesbos.
Lesbos by XDHAI!!!!!! May 28, 2015
Meaning 'a lesbian'; A female who enjoys sexual relations with other females.
A: "Do you know, Sam?"
B: "Yeah she's lesbos."
A: "Really?"
B: "Lesbos."
lesbos by Lojo March 22, 2007
Nickname for lesbians, women who enjoy sexual relations with other females.
A:Hey do you know that girl watching Elf?
B:Who Katie?
A:Yeah I hear she is a total Lesbian with Bri
B:Really?
A: Yea man Lesbos
lesbos by price89 November 14, 2009
When a guy is transitioned to a transgender woman and likes girl .
, oh look that’s not a lesbian that’s lesbos since is born a guy . Oh look at those two happy lesbos , why lesbos because they were born guys . Have you seen south park episode with the lesbos .
Lesbos by Huose del Garden November 10, 2022

island of lesbos 

Woman dominated land where all women have super human strength. Men feel inferior on the island of lesbos.
After a 15 mile run these women are going to surf 30 foot waves and then take it to the street for some good old-fashioned ass kicking. Smart cocktails to follow. Men feel inferior and insecure on the island of lesbos.
island of lesbos by runbucky January 11, 2021

resident of the isle of lesbos 

Female who prefers the intimate company of other females.
Jimbo: Man, Dykena is pretty hot.
Billy Joe: Don't bother. She's a resident of the isle of lesbos.