It virtually means: what's going on, how are you doing, what's happening, etc...it is a saying that is Born, Bred and Said by most Detroit Natives.(may also be spelled, "What Up Doe")
The man walked into the store and as he passed a young man that was leaving out and he said to him, Whudupdoe? The young man said the same in return. A simple greeting of affection and acknowledgment of people you pass, meet or greet!
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).
Precedes or follows either a gratuitously disrespectful or honest remark, originated in New York City. Used in similar fashion to "no offense" or "to be honest," interchangeably.
Ya mans is wild buns, respectfully. Respectfully he's washed.
After school, The Modells on Jamaica Ave was active. Respectfully.