To be Up and Fidgity From doing Crystal Meth.
When It's 4 AM U havent slept for days and Ur still wide away your TWEAKING
by Lisa April 9, 2004
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to fuck with
"tweak with my squad and we'll catch a body"
by just sumbody December 5, 2014
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1) to be stimulated by consuming high amounts of caffeine or sugar.
2) to use amphetamine or methamphetamine.
i drank 3 monster drinks and ate a few candy bars at the skatepark and i was seriously tweakin'

a grip of anphetamine pills or a couple of lines of meth can cause you to tweaki all night.
by skaterjack October 5, 2006
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1. to go beyond extension, or stretching. as in the truth, a snowboard grab, or a body part.

2. to freak out while you're on drugs. (Usually used in correlation with meth users).
Hey, so you kind of tweaked the story a bit, I don't appreciate that.

Did you see him tweak that sick-ass stale fish?

Dude, I can't skate today-- I tweaked my ankle yesterday falling down 3 flights of stairs.

That Guy is fucking tweaking out. Someone shoot him with a super soaker!
by rustyn! September 27, 2008
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1. To be under the effects of amphetamines, esp. crystal methamphetamine hydrochloride.

2. To be nervous or worried about something, esp. the presence of law-enforcement personnel.
1. Dude I took a fat hit of some dank ice and I'm tweaking balls!

2. Dude I got pulled over with an o in my glove compartment and I was tweaking balls!
by Bri90 January 28, 2010
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Bradley was tweaking after he took crack
by Bradley Fox February 1, 2018
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