To dance in a particular way referencing Bobbie Shmurda's song "hot nigga".
by Bholmes_xo November 26, 2014
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Someone who overly acts weird, reacts in a weird way, or acts unnormal and squarish.
When a teen acts too excited in class and starts tweaking out.
by magsoldier15 January 21, 2011
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Having a good time

It can be used as a substitute for "drinking", "partying", etc
Paul sure is tweaking

Oh, those fiends be tweaking tonight!
by Luov February 3, 2011
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a legitmate word meaning to pluck, or pull, and other non slang variations, but the slang variant was originally used to indicate the stage of a drug induced high, usually immediately following dosing, that indicates the climax of the high and the shift from sobriety into being extreme intoxication. Users were left alone when they "tweak," or are "tweaking out" until the initial strong effects of the drug wore off a little and they were more coherent.

The term has come to loosely refer to being high on speed, as well as unfortunately children who have been exposed to meth amphetamines in utero, parodied on shows including South Park.
You might act a little crazy when you tweak, but you'll come down in a minute or two.
by Lady Artemis April 3, 2010
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twisted generally related to events perceived while on hallucinogenic drugs, usually referring to an individual.
"Man, last night I dropped five microdots and ran up primrose hill naked! Boy was I tweaked!"

"I was out for a stroll on primrose hill last night and I saw a naked guy running around. He looked HIGHLY tweaked!"
by Simon November 10, 2004
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Street name for vitamin b6. AKA hack/beesicks. Commonly used for assisting the consumer in having a lucid dream.
Jordan hooked me up with some tweak, it was dope.
by Michael November 23, 2004
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