A word most often used with the pretext "to pull a", this meaning of the word originated in Arroyo Grande, and refers to a resident who own a .50 cal handgun, and is the definintion of "badass"
Victor: Yo! Come watch me smoke this fool!
Tyler: Hey man! Calm down, you're about to pull a Tweak!
by k man gg May 6, 2009
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To do crack or act like doing crack/cocaine.

Most of the time used in a question
"Gave who some dam money? I aint gave no nobody no damn money girl! IS YOU TWEAKING!?" By R-kelly Real Talk
by HondaKiller2TGR June 19, 2008
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A meth addict who is stuck doing pointless actions for long periods of time.
After hours of tweak activities, Theodore finally fell asleep.
by Juice Jonson February 26, 2018
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To stimulate a female's clitoris to the point of a micro-orgasm.
To the theme song tune of 'Kim Possible'. Call me beep me if you wanna tweak me.
by Kimfuckable May 3, 2019
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To not relax; to not chill; to mimic someone suffering from a unique combination of schizophrenia and terets, presenting a lack of logical thought upon speaking.
Don't tweak bro, relax.

I'm chill man, I never tweak on acid.

Relax for a second, or you might start to tweak.
by TweakOrBust December 4, 2017
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when you have a freak out .

When you go ape shit.
I'm gonna tweak the fuck out!

Bro, that kid fucked with me and i tweaked on him!
by pegasus12344 December 26, 2018
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