The word said by the legend Stewie2k-The Smoke Criminal
Stewie:Throws smoke and proceed to walk/spray
Stewie:Sup bitch
by XDMan123 June 2, 2019
Sup bitch is normally used to act non surprised or just pissed off at someone
Friend: “your a retard

You: next day when you see him “sup bitch”
by Thicccboii69 March 30, 2019
what you say to get hoes! I'll be cruising in my 68 impala wit my hydros goin bleep bleep... Dammmmmn I'll be like sup bitches!
Yo wassssup bitches!!
by Sup bitches April 24, 2004
The word(s) "sup bitch?" meaning is "what's up female dog" or "what is up female dog" sup bitch is usually also used to insult someone.
Sup bitch? Nothin faggot, what about you?
by The real Samuel June 2, 2012
The most manly way to trash-talk one about one's death. From the XBOX360 game "Gears of War".
Locust: *death gurgle*
Dom: 'Sup bitches?
by Mitch2 June 12, 2008
Phrase coined by Chad ‘Daddy’ Warden

Used to assert dominance
Chad:Sup Bitches
Person:There goes chad again, being an absolute alpha male
by FreeObamaCare March 8, 2020
Usually is to say hello to a hoe or a girl you hate.
Becky:Hi John
John:Sup Bitch
by Tzubba August 5, 2020