The result of when someone tells you something highly unbelievable, or just plain surprising. It can also be used elsewhere, such as when you're dissed. Basically a vulgar form of excuse me.
Ms. Garrison - "So there you go! You're the retarded offspring of five monkeys having butt sex with a fish-squirrel! Congratulations!”
Me - Ex-the-fucking-scuse-me?
The shorted ill-tempered short-mannered way of saying, "excuse me.” This variation is often used in situations where there is a hot, uncomfortable room full of smelly, ignorant, crowded, deaf people that never feel like getting the hell out of anyone’s way. Rather than wasting precious time and energy and giving them the graceful kind pardon of saying "excuse me" one must use the word in its other more rude and assertive context.