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It has two meanings, 'Sure' and 'Shit'. It all depends on the way you say it.
Sure - 'Fo Shizzle' = For Sure, Definately

Shit - 'That's The Shizzle' = That is good.
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In response to a yes or no question, can be used as "Fo' shizzle", meaning "For sure."
by Giarc December 20, 2003
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Shizzle=Sure
Its just when u take the last part off of the end of the word and replace it with izzle.
by Little white girL September 30, 2003
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a word which is funny to say when you get bored, you can randomly say shizzle, and then if the person you're talking to has any brain cells they will say on da hizzle or something completely pointless and stupid like that, it is weird and lame but it fills up hours (it works best if black people say it, i don't know why) and then when you get sick of this pointless crap you can say bizzle which sounds a bit like bye or gizzle (going) or gizzle fizzled nizzle (get fucked noob)etc etc
me:fo shizzle
dude: on da hizzle
me: zizzle
dude: frizzle mizzle
(four hours of pointless moronic izzle noises ensue)
me: gizzle fizzled whizzle
dude: bizzle
me: (unable to bear it any longer)SHUT UP!!!!!!!!!!
by Moominbaybee May 29, 2008
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