shalupee Share definition Flag a best friend . a mix between fruitlupee and shanaynay. a ghetto nickname. basically a fly sista from da hood. cant live without her Guy: who b dat fly honey Other Guy: damn she must be a shalupee shalupee by CASA BLANCA December 17, 2013 0 0 Get merch Get the shalupee mug. Buy Now — $32.95 See more merch