Commonly used as a replacement for "up" in the phrase "what's up?". Sees some usage outside this setting, though these are typically explicit in nature.
What's popin B? Let'shit up the thrift store and buy a couch!
12 step recovery jargon referring to someone new who talks about how great life is, now that they'resober. Usually meaning that the person is out of touch with reality.
The new guy seems pretty happy for a dude who has no job, no money and no family. He must be on a pink cloud.