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Commonly used as a replacement for "up" in the phrase "what's up?". Sees some usage outside this setting, though these are typically explicit in nature.
What's popin B? Let'shit up the thrift store and buy a couch!
Popin by McDaddy's Big Patties November 8, 2017
Street youth slang for asking what's happening or going on.
Yout one- my nigga
Yout two- what's popin
Yout one- Na it's dead you know
Popin by Twe December 30, 2016
popin... uh used by most crips or whom ever
yo cuddie whats popin yo
whats popalockin
then they will go CLLLAAAAAATTTT
popin by big emmanuel from NY March 14, 2004

popin and lockin in my rearview 

caused by late night driving ussualy between the hours of 2am and 5am where you seem to notice freaky shit that is not really there
dude something just rolled outa the ditch and was "popin and lockin in my rearview" wtf

popin a weedle

to become erect, to have an erection.
now dont go popin a weedle over my girlfriend, she's taken.
popin a weedle by valois16 January 11, 2011

popin a randy 

When a male pops a random boner "randy" so they call it "popin a randy"
Omg man Janes ass is so nice it's makin me pop a randy ! popin a randy