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The act of getting intentionally obliterated by alcohol in pursuit of a good time. More thorough than "going out for drinks" - you know damned well you won't be driving home from a proper piss-on.
Girl: "Why did Larry just drop his keys in the fish tank?"

Guy: "He's been looking forward to this party all week - he pegged it as a piss-on on Wednesday!"
piss-on by The Evil Steve August 30, 2005
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to disrespect and give attitude to someone who deserves it
Anita: "He wants to know about the textbooks."
Josie: "Mannn he's such a loser! Piss on him!!!"
piss on by AnitaBonita!! September 16, 2008
it means not giving a damn about someone or something.

also means that you're better than another person.
man, I piss on that little Wap, he's not even worth my time.
piss on by KRHimself August 2, 2004
To approach and annoy or harass, the opposite of when someone pisses off.
"Shit, I think John's about to piss on."
"Let's split, I hate that douchebag."
piss on by HoboAC February 26, 2008
For one thing to be excessively superior to something else, usually used to compare two similar things like computer games or bands of the same genre.
Dream Theater pisses on Symphony X.

Total Annihilation pisses on Red Alert.
When a male wakes up in the middle of the night having to piss so bad that it looks like a boner. Sometimes it is rather difficult to actually piss with a piss on, but it is extremely effective for holding a nut.
Damn, I woke up last night with the biggest piss on. Then, I screwed my girl for an hour without busting my nut.
piss on by Micah A. May 3, 2008
To approach and annoy or harass, the opposite of when someone pisses off.
"Shit, I think Richard's about to piss on."
"Let's split, I hate that douchebag."
piss on by HoboAC February 26, 2008