To get shot with a sniper rifle or long distance fire.

Most commonly used / heard in Rockstar Games' Grand Theft Auto V Online.
GTA Online DM:
ChuckNorris-RHK picked off boogie1954
BigDick666 picked you off
You picked off NoobGamr231
by tommi2 spaghetti March 18, 2014
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Something you say to blow off a dude trying to pick you up at a bar. A portmanteau of pick-up and blow-off.
OMFG! This total loser was flirting with me and I just wanted him to shut the fuck up and I said "Sorry, I like boys with tattoos" then he shows me his back and he has a huge like artwork thing on the back! Worst pick-off line ever!

I had a great pick-off line the other day. I was like "sorry, dude. I'd love to talk to you more, but I have some over-ripe fruit at home and I'm itching to bake it into a pie."
by ParchÞeSkald May 23, 2014
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A shortened version of "pick your shit up and get the fuck out", an insult similar to "Piss off" but with emphasis to the person's personal belongings and or problems.
Chunky told George to Pick Off! when he was being rude and impolite.
by chunky pawps July 3, 2015
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a prostitute; slut; a person who sleeps with so many guys
Sarah slept with 5 guys. She's such a pick off.
by LoL@27 December 4, 2017
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When you've made it to third base with a girl, but you get shut down before either one of you reaches orgasm.
Dude #1: You finally seal the deal with her last night?

Dude #2: Nah, man, I got picked off third.
by Morty Apples July 26, 2014
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