When a person is annoying me specifically
He keeps interrupting me when I am busy, so he is a pain in my ass.
by Jess Z October 22, 2008
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Someone whose sole existence is to piss you off and bother you.
John, you are being a really big pain in my ass today.
by Happy wife happy life July 2, 2015
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Ouch, I need to go to the doctor because I have pain in my ass.
by Andav October 22, 2008
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