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When someone is said to "need a cheeseburger" it means that the person is way too thin - so much so that the person doesn't look attractive. The implication is that the person is anorexic / dieting too much and needs to put on some weight. Almost always said about a female but a male isn't immune.
"Damn, did you see how skinny Angelina Jolie looked at the Academy Awards the other night? That girl needs a cheeseburger!"

"LeAnn Rimes looks anorexic. Someone please give her a cheeseburger!"
by kayemmdee March 17, 2012
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Oct 31 Word of the Day
1. acronym for Laugh Out Loud + sob -- an expression for something that makes you lol and cry at the same time.

2. acronym for Laugh Out Loud, Son of a Bitch. An expression of bitter anger over something funny.
That fatal clown car accident made me lolsob-- clown cars are funny but my best friend was driving.
by duenna9 October 12, 2009
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