Commonly used by people with a background in psychology, the term "taking a neat one" refers to the act of downing a shot of substance (typically a shot of semen) without any other substance that could potentially impede the solution.
Connor: I had two shots last night.
Amy: Neat ones or no?
Connor: Neat. Always neat.
Amy: I don't blame you - can't have anything obstructing the fluid.
Amy: Neat ones or no?
Connor: Neat. Always neat.
Amy: I don't blame you - can't have anything obstructing the fluid.
by Elimo Flava November 18, 2014