hormone blockers

Hormone blockers, also known in some contexts as puberty blockers, are used by transsexuals to block various sex hormones. For instance spironolactone, a diuretic, is often prescribed to male-to-female transgender persons to block androgens or male hormones.

A hormone replacement therapy (HRT) regimen usually consists of at least two prescription drugs: hormone blockers to block the original hormones, plus a new, replacement hormone in the desired gender. For instance, an M2F transgender patient may be given spironolactone to block male hormones (androgens, testosterone) plus a female hormone such as estrogen (Premarin, a drug made from pregnant mares' urine, for example).

Once the original genitals (testicles or ovaries) are removed, the blocker is discontinued, leaving just the hormone replacement.

hormone blockers by bitchuck August 31, 2024

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bullshot

n. A screenshot fabricated by a company to misrepresent the graphics of a game; a combination of the words bullshit and screenshot.

Originated from Penny Arcade, a popular gaming webcomic.

-Have you seen Madden 2006 for the Xbox 360? The graphics are gonna be awesome!
-Dude, the Madden 2006 images they showed at E3 were bullshots. It doesn't look nearly as good as they said.

bullshot by Worker Unit #503,298,545 September 26, 2005

Word of the Day on July 15, 2026

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Gayborhood

N. A neighborhood containing homes, clubs, bars, restaurants, and other places of business and entertainment that cater to homosexuals.

"They've opened up a new club in the Gayborhood called the Male Box."

Gayborhood by Mia Shields January 6, 2006

Word of the Day on July 14, 2026

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kenlet

A small piece of information. Derived from the word ken, used often in the scottish language and is synonymous with knowledge.

Person 1: "Hey I don't get this shit. How do you solve this problem?"
Person 2: "I got that one. Give me some kenlets on this assignment and I'll help you w/ that one."

kenlet by Norma Y. October 8, 2005

Word of the Day on July 13, 2026

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I mean I guess bro

a word of expression to when you give up on comprehending someone's words of ignorance, stupidity, absurdity or are too exhausted to formulate a proper response.

Commonly seen in TikTok comment sections in replies to lazy attempts at humor, overconfidentally incorrect statement, or an over-the-top comment or when someone completely misses the mark on something.

"actually... incorrect statement, hope this helps!"
"I mean I guess bro"

I mean I guess bro by clydedrewblood June 24, 2026

Word of the Day on July 12, 2026

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abandonware

n. software that is no longer sold or supported by the original publisher / developer, often found as free downloads on the internet because it cannot be obtained elsewhere. Not legal, but often seen as morally acceptable because the company that made it is no longer selling the title, nor releasing it as freeware, therefore abandonware is "keeping the game alive", so to speak.

Doom II is not abandonware because id still sells it, while The Incredible Machine is not sold, therefore is abandonware.

abandonware by Spoom October 24, 2003

Word of the Day on July 11, 2026

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Foot prisons

Socks. Annoying, sweat-causing, non-barefoot enducing, everyday socks.

The first thing I do when I take off my shoes, is rip off the foot prisons I had to wear inside them. That's why I prefer flip flops, even in winter!

Foot prisons by Jackalope Hunter December 13, 2022

Word of the Day on July 10, 2026

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