d.s

short for down sindrome which some fool shortened to d.o but still it stands for the result of having a really ugly person

that girl has down sindrome

by thug#1 July 13, 2003

d.s.

Drug squad

Look out for me
Let's trip on L.S.D.
Look out for me
D.S. look out for me

by tijfg July 21, 2008

d.s.

Acronym. Doggystyle. When a man bends over or mounts a woman for the purpose of fornicating.

Hey Sara, that was some great D.S. last night.
I wouldn't mind slamming against those cheecks again!

by Brain Food February 29, 2008

D.S.

Initialism for "dick suck".

Fellatio.

"I got me a 'D.S.' from that skanky chick from down the street."

by David P. January 24, 2008

D.S

To get real real drunk and jump into a canal during the day. To get hopped up on pudding and bud lite and jump into body of water

yo! did you hear about Dave. He was having some bud lights at scotty's and decide to do a D.S

by Sharkton January 26, 2011

d.s.

Dip Shit

Only a d.s. would make fun of someone with down syndrome.

by Fredro February 15, 2004

D.S

A term that originated and was popularized in Sudbury, Ontario. Short for Down Syndrome, it is used in a less offensive way or when it would be otherwise inappropriate, ie in public. Used as a remark on the general stupidity of someone/something or a recent event.

Guy 1 : Man, Dave is really pissing me off today!

Guy 2 : Why? What did he do?

Guy 1 : He's just being a D.S and it's really annoying.

Bob: Did you see what Liam did at the party last night?

Mark: Oh my god I know dude sooo fucking D.S

Guy: Fuck! I've been trying to open this jar for ten minutes, this is so D.S !

by the-chiefs January 18, 2016