butthole disease 

Having to take a shit all of the time while having one or more of the various irritable bowel diseases.

It is hard to go anywhere for long periods of time because of my butthole disease.

butthole disease by sypha-dius July 11, 2016

big nigga skin butthole disease 

a nigga thats a butthole and he has a skin disease

big nigga skin butthole disease

big nigga skin butthole disease by AshkAhsss March 10, 2020

Spicy butthole disease

When you consume spicy foods and you feel like it's not gonna come out good later.

I'm gonna have spicy butthole disease later.

Or

I have spicy butthole disease.

Spicy butthole disease by ghostlypeachess February 13, 2020

Axel butthole disease 

Happens every National Axel Chavez Butthole day when a short stunt Mexican who weights 60 tons butthole gets extra tight to the point where not even any air gets through

“Richie: hey Axel it’s national Axel Chavez butthole day!”
“Axel: I can’t it’s too tight because of Axel butthole disease.”
“Richie: I don’t care spread them cheeks.”

Axel butthole disease by SkibiditolietRizz April 25, 2024