Having to take a shit all of the time while having one or more of the various irritable bowel diseases.
It is hard to go anywhere for long periods of time because of my butthole disease.
by sypha-dius July 12, 2016
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When you consume spicy foods and you feel like it's not gonna come out good later.
I'm gonna have spicy butthole disease later.

Or

I have spicy butthole disease.
by ghostlypeachess February 13, 2020
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