Simply when one consumes a HOT-RAIL up the shithole instead of the sniff hole. (HOT-RAIL BEING METHAMPHETAMEENS thru a hot glass tube)
Bro 1: Yo dood! You ever done a BOOF-N-SPOOF!!!!????

Bro 2: Naw man whats that?

Bro 1: Dood! Its a hot rail throuu the butt yo! GETS YOU SO GEEKED AND TWEEKED!

Bro 2: Man! Sounds METHED UP!(spoken with happy excited energetic laughter) I can't wait to try it!
by Kevin MF DANGER! March 29, 2022
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SomuTana Mongeau said that Shane Dawson doesn’t understand
Tana: ew i get so emotional leaving shane & ryland & morgan i love them so much oof :’( my favorite humans

Also Tana: and I boof-

Shane: I just had to ask Siri what “boofing” was after Tana left my house.
by Tana’s dick June 17, 2019
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The form of, being chill or playing it cool.
Chris: Yo, I was boofing while Sarah’s fine ass was walking by.

Sebastian: Nice
by MERC157 July 8, 2019
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Smelling like shit/tuna/fish, just horrible in general
That girl was cute af and she was so thicc that her ass clapped when she walked but she was BOOFIN

She sits at the back of homeroom and whenever we get back to homeroom that shit be BOOFING.
by thesykeoh August 5, 2019
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The act of using substance threw ones rectum
Jack and the Taquche kid wont stop boofing
by 9nineeleven11 May 26, 2020
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The experience of blowing cocaine up a partners bum hole for sexual pleasure
Dan( jay can u blow cocaine up my bum for a new experience boofing sounds like fun )
Jay ( anything to make a friend happy )
by Whitelines84 June 13, 2020
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