Zach Syndrome Share definition Flag Zach Syndrome is a disorder in which the person says the N-word randomly or in every single sentence. Dude. He kept saying the N-word constantly. I think he has Zach Syndrome. Zach Syndrome by MousePad04 June 29, 2022 0 0 Get merch Get the Zach Syndrome mug. Buy Now — $32.95 See more merch