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Jack Blade quote from Tropic Thunder. His character was experiencing withdrawl from cocaine and he was tied to a tree. Crazy shit ensued.

Basically, It means your mother sleeps with everyone and has deseases between her legs, and most likely, you are unwanted crotchspawn.
"Your mother is a cankerous whore!"
"Damn."
"Hey, remember that time I called your mother a cankerous whore? I didn't mean it man, she's a nice lady." - Tropic Thunder
by Allie-Rose March 12, 2009
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