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How people who are too lazy to add a single apostrophe to a word, spell the phrase, "What's up?" (What-is-up?).
Man: Hey man! Whats up! I'm so lazy that I decided to leave the apostrophe out of "what's", that way I can conserve more energy. You know, because I oppose global warming and all that.
Whats Up by Hold My Umbrella June 15, 2011
term used when you did something badass
after slapping a bitch thats "whats up"

klucthing it
whats up by benjijuice18 July 26, 2009
Something you say to someone who looks sad or troubled
Hey whats up, u don't look like your happy self
Whats up by 20104u January 14, 2010
something you say when you bouta fight someone
Guy 1: Ay, whats up?

Guy 2: Whats up?
whats up by f1zzis0da July 11, 2024

Whats Up? 

What is happening wiht you, How are you, whats going on?
Something that LouAnn doesnt understand.

Usual response: Nothin Much
**Do not reply 'HI' or with another 'Whats Up'**

A common phrase that most people understand & use each day.
Carl: Hey Dude
Mark: Hey Whats up?
Carl: nothin much
Mark: Cool
Whats Up? by Ednabrowneye13 January 17, 2009

Whats up? 

What is happEnig friend
Whats up? by Kevin December 4, 2003