Uppers 

The term uppers is a street name for amphetamine-based psychostimulant drugs that produce increased wakefulness and focus, in association with decreased fatigue and appetite. Also referred to as speed, uppers are widely used recreationally as a performance enhancer for athletes and college students, and abused as a weight-loss supplement. In the United States, uppers are also consumed as a prescription to treat ADD (Attention Deficit Disorder) and ADHD (Attention Deficit Hyperactivity Disorder). Examples of these include the brand-named medications Adderall, Dexedrine, Dextrostat, Desoxyn, ProCentra, and Vyvanse, as well as Benzedrine in the past (due to high recreation use as early as the 1940's).

Other narcotic such as MDMA (ecstasy), methamphetamine (meth), and cocaine can also be colloquially referred to as uppers.

"Hey, could I buy uppers from you? I have a huge paper to write tonight."

Uppers by ILoveLamp12! September 30, 2012

uppers 

street classification of any prescription or non prescription substance that is a CNS stimulant, common physical side effects of "uppers" are:

increased heart rate
anxiety
tingling
feeling "buzzed"

Amphetamines (speed)
Methamphetamines (meth)
Ecstasy
Ephedrine and Psudo-Ephedrine
Cocaine and Crack

uppers by J January 10, 2004

uppers 

a drug that is a stimulant and makes you.. hyper. Some are crack and/or ectacsy <s/p>

I need some uppers to get through class today

uppers by Insane February 7, 2004

Happy Uppers 

Drugs taken to make one high, usually in the form of pills such as OxyCotin.

To be hopped up on happy uppers is to not have a care in the world.

Happy Uppers by OneBadAsp October 22, 2006

All of the downs and the uppers 

A reference to drugs, both depressants (downs) and stimulates (uppers). Commonly used together (alcohol and marijuana) to further remove one's self from reality than either one alone.

Tonight I'm trying all of the downs and the uppers

All of the downs and the uppers by kingjo3y June 13, 2016

leather uppers 

A thong on a flip flop sandal made entirely out of leather.

Flip Flops that have leather uppers are generally considered more presentable than those made out of foam or rubber.

I.E.
Teacher: Are those sandals in dress code sir?
Student: Yes sir, they have leather uppers just like they are supposed to.
Teacher: Good day.

leather uppers by talon7331 May 26, 2007

what's uppers 

What's popping my nigga? E-feezy style

What's uppers bitch, i'm a skeet all up on you

what's uppers by CH, CH ,CH, CHIMP UNIT!! May 7, 2005