UYB

UYB = Use Your Brain.
usually use for telling friends or jokes.

UYB, badass!!

by Suicideynxxx September 15, 2010

UYB

Acronym: Up Your Bum/Butt is a safer alternative to femoral injecting for drug users.

While UYB is a safer alternative for injectors it carries greater risks than other non-injecting ways of taking drugs such as smoking, swallowing, or snorting.

Drugs taken UYB have a faster and fuller effect than when smoked.

My groin is pinned to shit, gonna have to go UYB.

by EJO, UK August 1, 2008