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This is the acronym for "That's What I Said." Instead of saying, "That's What She Said" this works in instances where you have said the saying.
"Are you coming?"
"TWIS."
TWIS by VCRonna January 29, 2010
Related Words
"This is Why I'm Single"
"I'm homeschooled" #TWIS
TWIS by #TWIScreator September 5, 2012
This Week In Stupid
Beginning line to every TWIS:
Hello everybody and welcome to this week in stupid for (what every day)...
TWIS by Rousy Ronald November 3, 2017
Twis means to be under the influence of either drink or drugs
"i'm gunna get twis 2nyt"

"man iz twis"
Twis by MeRkLeMaN July 25, 2009
P1: "Damn, these sunglasses barely work"
P2: "Yeah, sun's bright af"
P1: "Bruh, twis"
TWIS by TheHazeFactory July 10, 2018
Someone that is super lazy and doesn’t care about a word you say
That boy is sooo Twis
Twis by —Reese— September 5, 2021