Predominantly used in spaces like Twitter:

When you see a tweet that perfectly sums up your thoughts like no other. so you retweet it with the caption, “This the one.”
by elcobells May 28, 2020
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BASKETBALL, where you (and only you) play against one other person
I played against Santiago in a one on one basketball game
by Home slice August 14, 2005
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An informal code of street fighting, not allowing bystanders to interfere in the fight.
Hey bitch-ass, let's square it up one-on-one in the midldle of the street!
by PGrace August 04, 2003
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a bag of heroin and coke together.
i wanted to do a speedball so i told my connect i need a "one and one" bag.
by fresh stallion April 12, 2010
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1. A game where the only opponents are two people playing against each other.
2. Also know as speedballing; a mixture of cocaine and herion, most often injected.
1. Jack says to Tommy, "Let's play a game of one on one"
2. After getting out of lock-up, I said to myself, "I'm 'bout ready to head downtown and gets me a one on one!!"
by dieselgirl August 07, 2003
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The person that makes you change everything you said you wouldn't ; put it down in every way ; the one you meant to be with ; time enough : able to control without force ; Mesmerizing
Boooooyyyyyyyy, You the one one!
by Aneres April 13, 2016
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san francisco bay area slang for a combination of cocaine and heroin, aka a "speedball". a hit of tar heroin and powder cocaine sold together on the street for $10 to $20.
if youre in a san francisco neighborhood such as the mission, and you hear a guy calling out "one on oners, one on oners", hes not challenging you to a game of basketball.
by beau "oma" taylor March 14, 2010
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