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42nd Street in New York City (the southernmost part of Times Square). Back in the day, a center of total depravity, especially between 8th and 9th Avenue, but currently Disneyfied.
'Man, I need to score, I'm gonna hit the Deuce.'
by anarcissie January 09, 2012
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3
1. 42nd St, Forty Deuce (42), or just the deuce meaning two.
2. The Devil.
3. An oustanding example, especially of something difficult or bad.
At the peak of the most infamous period in its history during the 1970s 42nd St (as well as the number two train which ran directly beneath Times Square) was referred to as 'The Deuce' or The Beast by police and criminals alike, notorious for its crime.
by Stephen Britt August 02, 2006
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5
The rear end of a girl, also known as the ass or the butt. The second of the two sexual holes, with the vagina being the first
Your Mom was a freak last night when she asked me to put it in the deuce
by Big Dick McGee June 08, 2004
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6
The ghetto.

I'm not sure how this slang came to be, but that's what it means.
"Strikin' through the deuce with a forty in my mouth"
-Brotha Lynch Hung (song- 24 Deep)

"Now I'm livin' up in the deuce and I can still get shot"
(same song)
by Jaynik March 15, 2008
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