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In role-playing games: Total Party Kill. Put even simpler, everybody is dead.
We weren't expecting to be TPKed by a giant rat!
by Yazzy July 09, 2005
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Town Portal Kill - derived from Diablo 2 gameplay. When a character lures a large group of enemies into a small area then opens up a town portal and safely heads to town. He then tells other player that the portal he just opened is safe & clear. The unknowing player jumps into the portal and get swarmed by enemies then dies.

TPKs are used regularly on Hardcore mode to kill off low level players quickly.
John: "My lv27 Hardcore warrior just got TPK'd by some asshole Hydra Sorc."

Me: "Daam, how'd that happen?"

John: "He said he was giving free Baal kills, so I jumped into the portal, and when the zone loaded up I was dead! He lured the entire fucking zone to the portal"

Me: "HAHA! That'll teach you to play pick-up games!"
by dee-rock July 25, 2008
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Othertimes known as Tight Pants Krew. A resepcted group of kids down in the Citys of Norfolk and Virginia Beach. These kids are true skaters and whoever plays with them gets delt with.
Joe:Why are all those fags wearing tights pants?
Tom: Bitch their in fucking TPK

Tom:Dude are those kids gay!?
Steve:Naw they jus roll deep in TPK.
by dont wanna tell November 30, 2006
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Team Pile Killers - Group of people that consume a massive pile of drugs
TPK's unite, we need to kill this pile!
by Chris1987wooh January 13, 2008
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TPK is an STD which is accompanied by Diarrhea and Vomiting along with large cauliflower shaped warts. The means of which are attained through sexual interactions with an unattractive mortal. Specifically, someone who is uncapable of smiling and frequently looks offensive. There is no found cure.
Dude whats wrong man?

Well I hooked up with a girl incapable of smiling and now I have the TPK.

Thats horrible sorry to hear that.

Yo son what's the deal wit the long face?

man my dick turned to a CAULIFLOWER piece of SHIT from TPK!

that's what you get, fool.
by The Wizards of the Infantry April 22, 2009
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