Skyrim syndrome 

When a video game (typically open world RPG, though there are exceptions) you feel an intense need to do as much as you possibly can. Named after the first game in which this phenomenon was observed, "the elder scrolls V: skyrim"

I started playing horizon zero dawn yesterday and I'm getting a severe case of skyrim syndrome from it

Skyrim syndrome by lolwaffles March 22, 2017

Skyrim Syndrome 

The unbearable feeling of emptiness, apathy, and utter anticipation felt before the release of the new Elder Scrolls game.

Dude 1: I didn't even feel like getting up this morning
Dude 2: Yeah. Skyrim syndrome.

Skyrim Syndrome by OctobersFate November 8, 2011

Skyrim syndrome 

A severely antisocial condition causing the sufferer to purposely bring about his own isolation from society so he is not in any way disturbed during playing Skyrm. In severe cases emotional bonds such as long-term relationships can be completely destroyed by this syndrome.

Francis: did you hear about Nathan?
Amy: no, what's up?
Francis: he hasn't talked or looked anyone in days.
Amy: what is it, is he depressed?
Francis: no, it's ... it's Skyrim syndrome
Amy: but that means, he will be lost to us for 300 hours or more!

Skyrim syndrome by buck-savage November 30, 2011