Snoop slang. It means for sure, my nigga.
Did you want to have tea and crumpets after we're done playing tennis jeeves? Jeeves replies, "Fo shizzle my nizzle!"
by JimC March 2, 2005
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oh darn
oh crap
oh shite
any other curse
oh shizzle manizol i broke my monkey fairy action figure that i got from monkeys 'r' us
by nimbus February 28, 2005
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