Shizzle Manizol Share definition Flag Snoop slang. It means for sure, my nigga. Did you want to have tea and crumpets after we're done playing tennis jeeves? Jeeves replies, "Fo shizzle my nizzle!" Shizzle Manizol by JimC March 2, 2005 0 0 Get merch Get the Shizzle Manizol mug. Buy Now — $32.95 See more merch