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Short for a computer painting software called "Paint tool Sai" or "Easy Paint tool Sai". It is known for also being simple to use for those learning how to draw on the computer.
"SAI is MS Paint and PS if they had sex."

guy1: "What program do you use for your drawings?"
guy2: "I use SAI."
by TTM123654789 January 23, 2012
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8
A Naruto Shippuuden character.
Has no feelings at all.
Looks kindda gay but is not.
Draws & makes those drawings come to life & battle.
A replacement of Sasuke.
Is an Anbu in the division Root.
Loves to do fake smiles (the only expression he knows).
Sai is so hot! He got nice abs!!
by Ms. Fluffy Butt March 31, 2008
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9
Also known as Eloisa, is a female that has looks beyond comprehension. Some people defines her as a princes, some as an angel, but for someone as his everything. A very enchanted person that inspires all that is around her - a perfect example of a modern woman.
Sai is the best thing that ever happened to me.
Sai! I love you very much!
by yellow bird spoon February 08, 2009
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10
He is a stupid little boy who likes to play girls like he plays soccer (even tho he sucks at it). he has a tiny dick.
(Girl 1) i had that guy over last night. you were right it wasn't worth it.
(Girl 2) i told he was Sai!!
by That Salty Bitch July 30, 2020
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11
(Sa'ih) A term of respect; can be roughly translated as sir or madam.
May also be written as "Sei"
Teacher: "Now, I've re-arranged seating to discourage you two from passing each other notes. I can not have either of you doing that during class. Have I made myself clear?"

Student 1: "Sai, of course."
Student 2: "Yes Sai!"
by wax-paper peace-pipe boi May 24, 2010
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12
Colloquial, in other countries- A lover who has to court in secret, generally female, due to social factors
He and his Sai had no choice but to make passioante love behind the bushes in Cubbon Park
by SuperAwesomeBob June 12, 2011
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13
vulgar, colloquial- An illicit lover
Oh he's got a wife but he's boning a Sai on the side
by SuperAwesomeBob June 12, 2011
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