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Safety First 

A reminder to engage in safe sex. Usually used when the people in question aren't actually planning on having sex, but the speaker is implying that they will be having sex.
Person A is leaving the party with person B, a platonic friend.

Person C: Safety first!
Safety First by luxi4r February 24, 2017

Safety First 

An extremely drunk individual who will quote risky business and piss all over Bozzo's neighbor's door.
Yo man, Safety First drank so much last night he ripped his shirt during planets
Safety First by Bperfan420 August 1, 2003

safety first 

safety first:
1) loves to rage
2) tour is life
3) the brothers past mascot
4) slinging bunk yay on lot
5) trying to talk to all the ladies
safety first by coolgirl April 18, 2005